Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues

Therapies addressing multiple stages of Plasmodium falciparum life cycle are highly desirable for implementing malaria elimination strategies. MMV019918 (1, 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine) was selected from the MMV Malaria Box for its dual activity aga...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Vallone, Alessandra, D’Alessandro, Sarah, Brogi, Simone, Brindisi, Margherita, Chemi, Giulia, Alfano, Gloria, Lamponi, Stefania, Lee, Soon Goo, Jez, Joseph M., Koolen, Karin J.M., Dechering, Koen J., Saponara, Simona, Fusi, Fabio, Gorelli, Beatrice, Taramelli, Donatella, Parapini, Silvia, Caldelari, Reto, Campiani, Giuseppe, Gemma, Sandra, Butini, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902032/
https://ncbi.nlm.nih.gov/pubmed/29571157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.03.024
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