In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors

Plasmodium falciparum subtilisin-like protease 1 (SUB1) is a novel target for the development of innovative antimalarials. We recently described the first potent difluorostatone-based inhibitors of the enzyme ((4S)-(N-((N-acetyl-l-lysyl)-l-isoleucyl-l-threonyl-l-alanyl)-2,2-difluoro-3-oxo-4-aminopen...

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Pubblicato in:J Mol Graph Model
Autori principali: Brogi, Simone, Giovani, Simone, Brindisi, Margherita, Gemma, Sandra, Novellino, Ettore, Campiani, Giuseppe, Blackman, Michael J., Butini, Stefania
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science, Inc 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5276822/
https://ncbi.nlm.nih.gov/pubmed/26826801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2016.01.005
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