Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins

Por Recacha, Rosario, Jaudzems, Kristaps, Akopjana, Inara, Jirgensons, Aigars, Tars, Kaspars
Publicado no Acta Crystallogr F Struct Biol Commun (2016)

Targeting Multiple Aminoacyl-tRNA Synthetases Overcomes the Resistance Liabilities Associated with Antibacterial Inhibitors Acting on a Single Such Enzyme

Por Randall, Christopher P., Rasina, Dace, Jirgensons, Aigars, O'Neill, Alex J.
Publicado no Antimicrob Agents Chemother (2016)

Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors

Por Recacha, Rosario, Leitans, Janis, Akopjana, Inara, Aprupe, Lilija, Trapencieris, Peteris, Jaudzems, Kristaps, Jirgensons, Aigars, Tars, Kaspars
Publicado no Acta Crystallogr F Struct Biol Commun (2015)

Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target

Por Withers-Martinez, Chrislaine, Suarez, Catherine, Fulle, Simone, Kher, Samir, Penzo, Maria, Ebejer, Jean-Paul, Koussis, Kostas, Hackett, Fiona, Jirgensons, Aigars, Finn, Paul, Blackman, Michael J.
Publicado em 2012

Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

Por Jaudzems, Kristaps, Tars, Kaspars, Maurops, Gundars, Ivdra, Natalija, Otikovs, Martins, Leitans, Janis, Kanepe-Lapsa, Iveta, Domraceva, Ilona, Mutule, Ilze, Trapencieris, Peteris, Blackman, Michael J., Jirgensons, Aigars
Publicado em 2014

A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus

Por Gupta, Arya, Monteferrante, Carmine, Rasina, Dace, Leitis, Gundars, Randall, Christopher P., Tomlinson, Jennifer H., Jirgensons, Aigars, Goessens, Wil H. F., Hays, John P., O'Neill, Alex J.
Publicado no Antimicrob Agents Chemother (2016)

N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors

Por Charlton, Michael H., Aleksis, Rihards, Saint-Leger, Adélaïde, Gupta, Arya, Loza, Einars, Ribas de Pouplana, Lluís, Kaula, Ilze, Gustina, Daina, Madre, Marina, Lola, Daina, Jaudzems, Kristaps, Edmund, Grace, Randall, Christopher P., Kime, Louise, O’Neill, Alex J., Goessens, Wil, Jirgensons, Aigars, Finn, Paul W.
Publicado no ACS Med Chem Lett (2018)