N-Leucinyl Benzenesulfonamides as Structurally Simplified Leucyl-tRNA Synthetase Inhibitors

[Image: see text] N-Leucinyl benzenesulfonamides have been discovered as a novel class of potent inhibitors of E. coli leucyl-tRNA synthetase. The binding of inhibitors to the enzyme was measured by using isothermal titration calorimetry. This provided information on enthalpy and entropy contributio...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Charlton, Michael H., Aleksis, Rihards, Saint-Leger, Adélaïde, Gupta, Arya, Loza, Einars, Ribas de Pouplana, Lluís, Kaula, Ilze, Gustina, Daina, Madre, Marina, Lola, Daina, Jaudzems, Kristaps, Edmund, Grace, Randall, Christopher P., Kime, Louise, O’Neill, Alex J., Goessens, Wil, Jirgensons, Aigars, Finn, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807874/
https://ncbi.nlm.nih.gov/pubmed/29456792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00374
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