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Crystal structure of Plasmodium falciparum proplasmepsin IV: the plasticity of proplasmepsins

Plasmepsin IV from Plasmodium falciparum (PM IV) is a promising target for the development of novel antimalarial drugs. Here, the crystal structure of the truncated zymogen of PM IV (pPM IV), consisting of the mature enzyme plus a prosegment of 47 residues, has been determined at 1.5 Å resolution. p...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Recacha, Rosario, Jaudzems, Kristaps, Akopjana, Inara, Jirgensons, Aigars, Tars, Kaspars
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012203/
https://ncbi.nlm.nih.gov/pubmed/27599854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16011663
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