A Polymorphism in leuS Confers Reduced Susceptibility to GSK2251052 in a Clinical Isolate of Staphylococcus aureus

GSK2251052 is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS) that has been evaluated in phase II clinical trials. Here, we report the identification of a clinical isolate of Staphylococcus aureus that exhibits reduced susceptibility to GSK2251052 without prior exposure to...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Gupta, Arya, Monteferrante, Carmine, Rasina, Dace, Leitis, Gundars, Randall, Christopher P., Tomlinson, Jennifer H., Jirgensons, Aigars, Goessens, Wil H. F., Hays, John P., O'Neill, Alex J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2016
Sujets:
Mechanisms of Resistance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4862542/
https://ncbi.nlm.nih.gov/pubmed/26976861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02940-15
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