Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogues for boron neutron capture therapy of cancer

A library of sixteen 2(nd) generation amino- and amido-substituted carboranyl pyrimidine nucleoside analogues, designed as substrates and inhibitors of thymidine kinase 1 (TK1) for potential use in boron neutron capture therapy (BNCT) of cancer, was synthesized and evaluated in enzyme kinetic-, enzy...

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Bibliografiska uppgifter
I publikationen:Eur J Med Chem
Huvudupphovsmän: Agarwal, Hitesh K., Khalil, Ahmed, Ishita, Keisuke, Yang, Weilian, Nakkula, Robin J., Wu, Lai-Chu, Ali, Tehane, Tiwari, Rohit, Byun, Youngjoo, Barth, Rolf F., Tjarks, Werner
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501388/
https://ncbi.nlm.nih.gov/pubmed/26087030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.05.042
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