Synthesis and evaluation of thymidine kinase 1-targeting carboranyl pyrimidine nucleoside analogues for boron neutron capture therapy of cancer

A library of sixteen 2(nd) generation amino- and amido-substituted carboranyl pyrimidine nucleoside analogues, designed as substrates and inhibitors of thymidine kinase 1 (TK1) for potential use in boron neutron capture therapy (BNCT) of cancer, was synthesized and evaluated in enzyme kinetic-, enzy...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Eur J Med Chem
Главные авторы: Agarwal, Hitesh K., Khalil, Ahmed, Ishita, Keisuke, Yang, Weilian, Nakkula, Robin J., Wu, Lai-Chu, Ali, Tehane, Tiwari, Rohit, Byun, Youngjoo, Barth, Rolf F., Tjarks, Werner
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4501388/
https://ncbi.nlm.nih.gov/pubmed/26087030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.05.042
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы