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Cellular Influx, Efflux, and Anabolism of 3-Carboranyl Thymidine Analogs: Potential Boron Delivery Agents for Neutron Capture Therapy

3-[5-{2-(2,3-Dihydroxyprop-1-yl)-o-carboran-1-yl}pentan-1-yl]thymidine (N5-2OH) is a first generation 3-carboranyl thymidine analog (3CTA) that has been intensively studied as a boron-10 ((10)B) delivery agent for neutron capture therapy (NCT). N5-2OH is an excellent substrate of thymidine kinase 1...

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Bibliografiske detaljer
Main Authors: Sjuvarsson, Elena, Damaraju, Vijaya L., Mowles, Delores, Sawyer, Michael B., Tiwari, Rohit, Agarwal, Hitesh K., Khalil, Ahmed, Hasabelnaby, Sherifa, Goudah, Ayman, Nakkula, Robin J., Barth, Rolf F., Cass, Carol E., Eriksson, Staffan, Tjarks, Werner
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807065/
https://ncbi.nlm.nih.gov/pubmed/24006340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.207464
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