Synthesis, Chemical and Enzymatic Hydrolysis, and Aqueous Solubility of Amino Acid Ester Prodrugs of 3-Carboranyl Thymidine Analogues for Boron Neutron Capture Therapy of Brain Tumors

Various water-soluble L-valine-, L-glutamate-, and glycine ester prodrugs of two 3-Carboranyl Thymidine Analogues (3-CTAs), designated N5 and N5-2OH, were synthesized for Boron Neutron Capture Therapy (BNCT) of brain tumors since the water solubilities of the parental compounds proved to be insuffic...

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Hlavní autoři: Hasabelnaby, Sherifa, Goudah, Ayman, Agarwal, Hitesh K., Abd alla, Mosaad S. M., Tjarks, Werner
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432695/
https://ncbi.nlm.nih.gov/pubmed/22889558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.07.033
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