Thymidine kinase 1 as a molecular target for boron neutron capture therapy of brain tumors

The purpose of the present study was to evaluate the effectiveness of a 3-carboranyl thymidine analogue (3CTA), 3-[5-{2-(2,3-dihydroxyprop-1-yl)-o-carboran-1-yl}pentan-1-yl] thymidine, designated N5–2OH, for boron neutron capture therapy (BNCT) of brain tumors using the RG2 rat glioma model. Target...

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Main Authors: Barth, Rolf F., Yang, Weilian, Wu, Gong, Swindall, Michele, Byun, Youngjoo, Narayanasamy, Sureshbabu, Tjarks, Werner, Tordoff, Kevin, Moeschberger, Melvin L., Eriksson, Staffan, Binns, Peter J., Riley, Kent J.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2008
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582264/
https://ncbi.nlm.nih.gov/pubmed/18981415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809569105
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