Small lipidated anti-obesity compounds derived from neuromedin U

A small library of truncated/lipid-conjugated neuromedin U (NmU) analogs was synthesized and tested in vitro using an intracellular calcium signaling assay. The selected, most active analogs were then tested in vivo, and showed potent anorexigenic effects in a diet-induced obese (DIO) mouse model. T...

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Vydáno v:Eur J Med Chem
Hlavní autoři: Micewicz, Ewa D., Bahattab, Omar S.O., Willars, Gary B., Waring, Alan J., Navab, Mohamad, Whitelegge, Julian P., McBride, William H., Ruchala, Piotr
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543588/
https://ncbi.nlm.nih.gov/pubmed/26204509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.07.020
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