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Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation

A small library of anticancer, cell-permeating, stapled peptides based on potent dual-specific antagonist of p53–MDM2/MDMX interactions, PMI-N8A, was synthesized, characterized and screened for anticancer activity against human colorectal cancer cell line, HCT-116. Employed synthetic modifications i...

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Detalhes bibliográficos
Publicado no:Int J Pept Res Ther
Main Authors: Micewicz, Ewa D., Sharma, Shantanu, Waring, Alan J., Luong, Hai T., McBride, William H., Ruchala, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779441/
https://ncbi.nlm.nih.gov/pubmed/26957954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10989-015-9487-3
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