Oxpholipin 11D: An Anti-Inflammatory Peptide That Binds Cholesterol and Oxidized Phospholipids

BACKGROUND: Many Gram-positive bacteria produce pore-forming exotoxins that contain a highly conserved, 12-residue domain (ECTGLAWEWWRT) that binds cholesterol. This domain is usually flanked N-terminally by arginine and C-terminally by valine. We used this 14-residue sequence as a template to creat...

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Autori principali: Ruchala, Piotr, Navab, Mohamad, Jung, Chun-Ling, Hama-Levy, Susan, Micewicz, Ewa D., Luong, Hai, Reyles, Jonathan E., Sharma, Shantanu, Waring, Alan J., Fogelman, Alan M., Lehrer, Robert I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854715/
https://ncbi.nlm.nih.gov/pubmed/20418958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010181
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