Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D

Following up the open initiative of anti-malarial drug discovery, a GlaxoSmithKline (GSK) phenotypic screening hit was developed to generate hydroxyethylamine based plasmepsin (Plm) inhibitors exhibiting growth inhibition of the malaria parasite Plasmodium falciparum at nanomolar concentrations. Lea...

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Bibliografske podrobnosti
izdano v:Eur J Med Chem
Main Authors: Zogota, Rimants, Kinena, Linda, Withers-Martinez, Chrislaine, Blackman, Michael J., Bobrovs, Raitis, Pantelejevs, Teodors, Kanepe-Lapsa, Iveta, Ozola, Vita, Jaudzems, Kristaps, Suna, Edgars, Jirgensons, Aigars
Format: Artigo
Jezik:Inglês
Izdano: Editions Scientifiques Elsevier 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336538/
https://ncbi.nlm.nih.gov/pubmed/30529637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2018.11.068
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