Engineering of a target site-specific recombinase by a combined evolution- and structure-guided approach
Site-specific recombinases (SSRs) can perform DNA rearrangements, including deletions, inversions and translocations when their naive target sequences are placed strategically into the genome of an organism. Hence, in order to employ SSRs in heterologous hosts, their target sites have to be introduc...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3575804/ https://ncbi.nlm.nih.gov/pubmed/23275541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1308 |
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