Engineering of a target site-specific recombinase by a combined evolution- and structure-guided approach

Site-specific recombinases (SSRs) can perform DNA rearrangements, including deletions, inversions and translocations when their naive target sequences are placed strategically into the genome of an organism. Hence, in order to employ SSRs in heterologous hosts, their target sites have to be introduc...

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Hlavní autoři: Abi-Ghanem, Josephine, Chusainow, Janet, Karimova, Madina, Spiegel, Christopher, Hofmann-Sieber, Helga, Hauber, Joachim, Buchholz, Frank, Pisabarro, M. Teresa
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575804/
https://ncbi.nlm.nih.gov/pubmed/23275541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1308
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