Engineering of a target site-specific recombinase by a combined evolution- and structure-guided approach

Site-specific recombinases (SSRs) can perform DNA rearrangements, including deletions, inversions and translocations when their naive target sequences are placed strategically into the genome of an organism. Hence, in order to employ SSRs in heterologous hosts, their target sites have to be introduc...

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Bibliografiske detaljer
Main Authors: Abi-Ghanem, Josephine, Chusainow, Janet, Karimova, Madina, Spiegel, Christopher, Hofmann-Sieber, Helga, Hauber, Joachim, Buchholz, Frank, Pisabarro, M. Teresa
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Nucleic Acid Enzymes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575804/
https://ncbi.nlm.nih.gov/pubmed/23275541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1308
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