Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

Sequence-specific endonucleases recognizing long target sequences are emerging as powerful tools for genome engineering. These endonucleases could be used to correct deleterious mutations or to inactivate viruses, in a new approach to molecular medicine. However, such applications are highly demandi...

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Detalhes bibliográficos
Main Authors: Grizot, Sylvestre, Smith, Julianne, Daboussi, Fayza, Prieto, Jesús, Redondo, Pilar, Merino, Nekane, Villate, Maider, Thomas, Séverine, Lemaire, Laetitia, Montoya, Guillermo, Blanco, Francisco J., Pâques, Frédéric, Duchateau, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760784/
https://ncbi.nlm.nih.gov/pubmed/19584299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp548
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