Context dependence between subdomains in the DNA binding interface of the I-CreI homing endonuclease

Homing endonucleases (HE) have emerged as precise tools for achieving gene targeting events. Redesigned HEs with tailored specificities can be used to cleave new sequences, thereby considerably expanding the number of targetable genes and loci. With HEs, as well as with other protein scaffolds, cont...

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Bibliographic Details
Main Authors: Grizot, Sylvestre, Duclert, Aymeric, Thomas, Séverine, Duchateau, Philippe, Pâques, Frédéric
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152339/
https://ncbi.nlm.nih.gov/pubmed/21482539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr186
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