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Context dependence between subdomains in the DNA binding interface of the I-CreI homing endonuclease

Homing endonucleases (HE) have emerged as precise tools for achieving gene targeting events. Redesigned HEs with tailored specificities can be used to cleave new sequences, thereby considerably expanding the number of targetable genes and loci. With HEs, as well as with other protein scaffolds, cont...

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Détails bibliographiques
Auteurs principaux: Grizot, Sylvestre, Duclert, Aymeric, Thomas, Séverine, Duchateau, Philippe, Pâques, Frédéric
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152339/
https://ncbi.nlm.nih.gov/pubmed/21482539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr186
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