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Homing endonuclease I-CreI derivatives with novel DNA target specificities

Homing endonucleases are highly specific enzymes, capable of recognizing and cleaving unique DNA sequences in complex genomes. Since such DNA cleavage events can result in targeted allele-inactivation and/or allele-replacement in vivo, the ability to engineer homing endonucleases matched to specific...

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Main Authors: Rosen, Laura E., Morrison, Holly A., Masri, Selma, Brown, Michael J., Springstubb, Brendan, Sussman, Django, Stoddard, Barry L., Seligman, Lenny M.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2006
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635285/
https://ncbi.nlm.nih.gov/pubmed/16971456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl645
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