Homing endonuclease I-CreI derivatives with novel DNA target specificities

Homing endonucleases are highly specific enzymes, capable of recognizing and cleaving unique DNA sequences in complex genomes. Since such DNA cleavage events can result in targeted allele-inactivation and/or allele-replacement in vivo, the ability to engineer homing endonucleases matched to specific...

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Hlavní autoři: Rosen, Laura E., Morrison, Holly A., Masri, Selma, Brown, Michael J., Springstubb, Brendan, Sussman, Django, Stoddard, Barry L., Seligman, Lenny M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2006
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635285/
https://ncbi.nlm.nih.gov/pubmed/16971456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl645
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