Homing endonuclease I-CreI derivatives with novel DNA target specificities

Homing endonucleases are highly specific enzymes, capable of recognizing and cleaving unique DNA sequences in complex genomes. Since such DNA cleavage events can result in targeted allele-inactivation and/or allele-replacement in vivo, the ability to engineer homing endonucleases matched to specific...

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Detalhes bibliográficos
Main Authors: Rosen, Laura E., Morrison, Holly A., Masri, Selma, Brown, Michael J., Springstubb, Brendan, Sussman, Django, Stoddard, Barry L., Seligman, Lenny M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635285/
https://ncbi.nlm.nih.gov/pubmed/16971456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl645
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