A protein architecture guided screen for modification dependent restriction endonucleases

Modification dependent restriction endonucleases (MDREs) often have separate catalytic and modification dependent domains. We systematically looked for previously uncharacterized fusion proteins featuring a PUA or DUF3427 domain and HNH or PD-(D/E)XK catalytic domain. The enzymes were clustered by s...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lutz, Thomas, Flodman, Kiersten, Copelas, Alyssa, Czapinska, Honorata, Mabuchi, Megumu, Fomenkov, Alexey, He, Xinyi, Bochtler, Matthias, Xu, Shuang-yong
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765204/
https://ncbi.nlm.nih.gov/pubmed/31504772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz755
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