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On the role of steric clashes in methylation control of restriction endonuclease activity

Restriction-modification systems digest non-methylated invading DNA, while protecting host DNA against the endonuclease activity by methylation. It is widely believed that the methylated DNA would not ‘fit’ into the binding site of the endonuclease in the productive orientation, and thus steric clas...

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Publicat a:Nucleic Acids Res
Autors principals: Mierzejewska, Karolina, Bochtler, Matthias, Czapinska, Honorata
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705667/
https://ncbi.nlm.nih.gov/pubmed/26635397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1341
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