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On the role of steric clashes in methylation control of restriction endonuclease activity

Restriction-modification systems digest non-methylated invading DNA, while protecting host DNA against the endonuclease activity by methylation. It is widely believed that the methylated DNA would not ‘fit’ into the binding site of the endonuclease in the productive orientation, and thus steric clas...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Mierzejewska, Karolina, Bochtler, Matthias, Czapinska, Honorata
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705667/
https://ncbi.nlm.nih.gov/pubmed/26635397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1341
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