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On the role of steric clashes in methylation control of restriction endonuclease activity

Restriction-modification systems digest non-methylated invading DNA, while protecting host DNA against the endonuclease activity by methylation. It is widely believed that the methylated DNA would not ‘fit’ into the binding site of the endonuclease in the productive orientation, and thus steric clas...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Mierzejewska, Karolina, Bochtler, Matthias, Czapinska, Honorata
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4705667/
https://ncbi.nlm.nih.gov/pubmed/26635397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1341
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