Structure and cleavage activity of the tetrameric MspJI DNA modification-dependent restriction endonuclease

The MspJI modification-dependent restriction endonuclease recognizes 5-methylcytosine or 5-hydroxymethylcytosine in the context of CNN(G/A) and cleaves both strands at fixed distances (N(12)/N(16)) away from the modified cytosine at the 3′-side. We determined the crystal structure of MspJI of Mycoba...

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Main Authors: Horton, John R., Mabuchi, Megumu Yamada, Cohen-Karni, Devora, Zhang, Xing, Griggs, Rose M., Samaranayake, Mala, Roberts, Richard J., Zheng, Yu, Cheng, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Nucleic Acid Enzymes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479186/
https://ncbi.nlm.nih.gov/pubmed/22848107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks719
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