Modification-dependent restriction endonuclease, MspJI, flips 5-methylcytosine out of the DNA helix

MspJI belongs to a family of restriction enzymes that cleave DNA containing 5-methylcytosine (5mC) or 5-hydroxymethylcytosine (5hmC). MspJI is specific for the sequence 5(h)mC-N-N-G or A and cleaves with some variability 9/13 nucleotides downstream. Earlier, we reported the crystal structure of MspJ...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Horton, John R., Wang, Hua, Mabuchi, Megumu Yamada, Zhang, Xing, Roberts, Richard J., Zheng, Yu, Wilson, Geoffrey G., Cheng, Xiaodong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231741/
https://ncbi.nlm.nih.gov/pubmed/25262349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku871
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