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The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix
Maintenance methylation of hemimethylated CpG dinucleotides at DNA replication forks is the key to faithful mitotic inheritance of genomic methylation patterns. UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is required for maintenance methylation by interacting with DNA nucleotide...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2602803/ https://ncbi.nlm.nih.gov/pubmed/18772888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07280 |
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