JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G(2)/M phase arrest, endoreduplication, and delayed apoptosis
The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking cell-cycle progression and inducing apoptosis. Despite extensive study, the mechanism by which SP600125 inhibits mitosis-related effects in human leukemia cells remains unclear. We investigated the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Korean Society of Medical Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753660/ https://ncbi.nlm.nih.gov/pubmed/19478553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2009.41.9.073 |
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