Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

The c-jun N-terminal kinase (JNK) signaling pathway is regulated by JNK-interacting protein-1 (JIP1), which is a scaffolding protein assembling the components of the JNK cascade. Overexpression of JIP1 deactivates the JNK pathway selectively by cytoplasmic retention of JNK and thereby inhibits gene...

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Detalhes bibliográficos
Main Authors: Heo, Yong-Seok, Kim, Su-Kyoung, Seo, Chang Il, Kim, Young Kwan, Sung, Byung-Je, Lee, Hye Shin, Lee, Jae Il, Park, Sam-Yong, Kim, Jin Hwan, Hwang, Kwang Yeon, Hyun, Young-Lan, Jeon, Young Ho, Ro, Seonggu, Cho, Joong Myung, Lee, Tae Gyu, Yang, Chul-Hak
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC419904/
https://ncbi.nlm.nih.gov/pubmed/15141161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600212
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