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SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition

Cell cycle controls ensure that DNA replication (S phase) follows mitosis resulting in two precise copies of the genome. A failure of the control mechanisms can result in multiple rounds of DNA replication without cell division. In endoreplication, cells with replicated genomes bypass mitosis, then...

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Autors principals: Kim, JA, Lee, J, Margolis, RL, Fotedar, R
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145494/
https://ncbi.nlm.nih.gov/pubmed/20062077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.464
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