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SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition
Cell cycle controls ensure that DNA replication (S phase) follows mitosis resulting in two precise copies of the genome. A failure of the control mechanisms can result in multiple rounds of DNA replication without cell division. In endoreplication, cells with replicated genomes bypass mitosis, then...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145494/ https://ncbi.nlm.nih.gov/pubmed/20062077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.464 |
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