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SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition
Cell cycle controls ensure that DNA replication (S phase) follows mitosis resulting in two precise copies of the genome. A failure of the control mechanisms can result in multiple rounds of DNA replication without cell division. In endoreplication, cells with replicated genomes bypass mitosis, then...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3145494/ https://ncbi.nlm.nih.gov/pubmed/20062077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.464 |
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