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JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G(2)/M phase arrest, endoreduplication, and delayed apoptosis
The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking cell-cycle progression and inducing apoptosis. Despite extensive study, the mechanism by which SP600125 inhibits mitosis-related effects in human leukemia cells remains unclear. We investigated the...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Korean Society of Medical Biochemistry and Molecular Biology
2009
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753660/ https://ncbi.nlm.nih.gov/pubmed/19478553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2009.41.9.073 |
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