JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G(2)/M phase arrest, endoreduplication, and delayed apoptosis

The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking cell-cycle progression and inducing apoptosis. Despite extensive study, the mechanism by which SP600125 inhibits mitosis-related effects in human leukemia cells remains unclear. We investigated the...

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Detalhes bibliográficos
Main Authors: Moon, Dong-Oh, Kim, Mun-Ock, Kang, Chang-Hee, Lee, Jae-Dong, Choi, Yung Hyun, Kim, Gi-Young
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society of Medical Biochemistry and Molecular Biology 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753660/
https://ncbi.nlm.nih.gov/pubmed/19478553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2009.41.9.073
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