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Understanding the Specificity of a Docking Interaction between JNK1 and the Scaffolding Protein JIP1

The up-regulation of JNK activity is associated with a number of disease states. The JNK-JIP1 interaction represents an attractive target for the inhibition of JNK-mediated signaling. In this study, molecular dynamics simulations have been performed on the apo-JNK1, and the JNK1•L-pepJIP1 and JNK1•D...

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Detalhes bibliográficos
Main Authors: Yan, Chunli, Kaoud, Tamer, Lee, Sunbae, Dalby, Kevin N., Ren, Pengyu
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042137/
https://ncbi.nlm.nih.gov/pubmed/21261310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp1073522
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