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A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach

The mechanisms by which MAP kinases recognize and phosphorylate substrates are not completely understood. Efforts to understand the mechanisms have been compromised by the lack of MAPK-substrate structures. While MAPK-substrate docking is well established as a viable mechanism for bringing MAPKs and...

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Main Authors: Lee, Sunbae, Warthaka, Mangalika, Yan, Chunli, Kaoud, Tamer S., Piserchio, Andrea, Ghose, Ranajeet, Ren, Pengyu, Dalby, Kevin N.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073974/
https://ncbi.nlm.nih.gov/pubmed/21494553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018594
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