SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Jun N-terminal kinase (JNK) is a stress-activated protein kinase that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation, and hypoxia. We report the identification of an anthrapyrazolone series with significant inhibition of JNK1, -2, and -3 (K(i) = 0.19 μM)....

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Bibliografski detalji
Glavni autori: Bennett, Brydon L., Sasaki, Dennis T., Murray, Brion W., O'Leary, Eoin C., Sakata, Steve T., Xu, Weiming, Leisten, Jim C., Motiwala, Aparna, Pierce, Steve, Satoh, Yoshitaka, Bhagwat, Shripad S., Manning, Anthony M., Anderson, David W.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC61101/
https://ncbi.nlm.nih.gov/pubmed/11717429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251194298
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