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Highly Potent Triazole-Based Tubulin Polymerization Inhibitors
We describe the synthesis and biological evaluation of a series of tubulin polymerization inhibitors that contain the 1,2,4-triazole ring to retain the bioactive configuration afforded by the cis double bond in combretastatin A-4 (CA-4). Several of the subject compounds exhibited potent tubulin poly...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2694353/ https://ncbi.nlm.nih.gov/pubmed/17249649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm061142s |
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