Development of a triazole class of highly potent Porcn inhibitors

The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. We have previously discovered four molecular scaffolds harboring Porcn-inhibitory activity. Comparison of their structures led to th...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: You, Lin, Zhang, Chengwei, Yarravarapu, Nageswari, Morlock, Lorraine, Wang, Xiaolei, Zhang, Lishu, Williams, Noelle S., Lum, Lawrence, Chen, Chuo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142825/
https://ncbi.nlm.nih.gov/pubmed/27876319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.11.012
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