Selective killing of p53-deficient cancer cells by SP600125

The genetic or functional inactivation of p53 is highly prevalent in human cancers. Using high-content videomicroscopy based on fluorescent TP53(+/+) and TP53(−/−) human colon carcinoma cells, we discovered that SP600125, a broad-spectrum serine/threonine kinase inhibitor, kills p53-deficient cells...

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Detalhes bibliográficos
Main Authors: Jemaà, Mohamed, Vitale, Ilio, Kepp, Oliver, Berardinelli, Francesco, Galluzzi, Lorenzo, Senovilla, Laura, Mariño, Guillermo, Malik, Shoaib Ahmad, Rello-Varona, Santiago, Lissa, Delphine, Antoccia, Antonio, Tailler, Maximilien, Schlemmer, Frederic, Harper, Francis, Pierron, Gérard, Castedo, Maria, Kroemer, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443949/
https://ncbi.nlm.nih.gov/pubmed/22438244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200228
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