AAA-ATPases in Protein Degradation

par Yedidi, Ravikiran S., Wendler, Petra, Enenkel, Cordula
Publié dans Front Mol Biosci (2017)

P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs again...

par Yedidi, Ravikiran S., Liu, Zhigang, Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C.
Publié dans J Mol Graph Model (2013)

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF

par Yedidi, Ravikiran S., Proteasa, Gheorghe, Martin, Philip D., Liu, Zhigang, Vickrey, John F., Kovari, Iulia A., Kovari, Ladislau C.
Publié dans J Mol Graph Model (2014)

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

par Yedidi, Ravikiran S., Liu, Zhigang, Wang, Yong, Brunzelle, Joseph S., Kovari, Iulia A., Woster, Patrick M., Kovari, Ladislau C., Gupta, Deepak
Publié 2012

Conserved Hydrogen Bonds and Water Molecules in MDR HIV-1 Protease Substrate Complexes

par Liu, Zhigang, Wang, Yong, Yedidi, Ravikiran S., Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Publié dans Biochem Biophys Res Commun (2012)

Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance

par Liu, Zhigang, Yedidi, Ravikiran S., Wang, Yong, Dewdney, Tamaria G., Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Publié dans Biochem Biophys Res Commun (2013)

GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants...

par Amano, Masayuki, Miguel Salcedo-Gómez, Pedro, Yedidi, Ravikiran S., Delino, Nicole S., Nakata, Hirotomo, Venkateswara Rao, Kalapala, Ghosh, Arun K., Mitsuya, Hiroaki
Publié dans Sci Rep (2017)

Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants

par Ide, Kazuhiko, Aoki, Manabu, Amano, Masayuki, Koh, Yasuhiro, Yedidi, Ravikiran S., Das, Debananda, Leschenko, Sofiya, Chapsal, Bruno, Ghosh, Arun K., Mitsuya, Hiroaki
Publié 2011

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants

par Yedidi, Ravikiran S., Proteasa, Georghe, Martinez, Jorge L., Vickrey, John F., Martin, Philip D., Wawrzak, Zdzislaw, Liu, Zhigang, Kovari, Iulia A., Kovari, Ladislau C.
Publié 2011

A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel N...

par Amano, Masayuki, Salcedo-Gómez, Pedro Miguel, Zhao, Rui, Yedidi, Ravikiran S., Das, Debananda, Bulut, Haydar, Delino, Nicole S., Sheri, Venkata Reddy, Ghosh, Arun K., Mitsuya, Hiroaki
Publié dans Antimicrob Agents Chemother (2016)

Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications

par Amano, Masayuki, Salcedo-Gómez, Pedro Miguel, Yedidi, Ravikiran S., Zhao, Rui, Hayashi, Hironori, Hasegawa, Kazuya, Nakamura, Tomofumi, Martyr, Cuthbert D., Ghosh, Arun K., Mitsuya, Hiroaki
Publié dans Antimicrob Agents Chemother (2019)

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HI...

par Yedidi, Ravikiran S., Muhuhi, Joseck M., Liu, Zhigang, Bencze, Krisztina Z., Koupparis, Kyriacos M., O'Connor, Carrie E., Kovari, Iulia A., Spaller, Mark R., Kovari, Ladislau C.
Publié dans Biochem Biophys Res Commun (2013)

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, includi...

par Aoki, Manabu, Hayashi, Hironori, Yedidi, Ravikiran S., Martyr, Cuthbert D., Takamatsu, Yuki, Aoki-Ogata, Hiromi, Nakamura, Teruya, Nakata, Hirotomo, Das, Debananda, Yamagata, Yuriko, Ghosh, Arun K., Mitsuya, Hiroaki
Publié dans J Virol (2016)

Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast

par Gu, Zhu Chao, Wu, Edwin, Sailer, Carolin, Jando, Julia, Styles, Erin, Eisenkolb, Ina, Kuschel, Maike, Bitschar, Katharina, Wang, Xiaorong, Huang, Lan, Vissa, Adriano, Yip, Christopher M., Yedidi, Ravikiran S., Friesen, Helena, Enenkel, Cordula
Publié dans Mol Biol Cell (2017)

P2′ Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiet...

par Yedidi, Ravikiran S., Maeda, Kenji, Fyvie, W. Sean, Steffey, Melinda, Davis, David A., Palmer, Ira, Aoki, Manabu, Kaufman, Joshua D., Stahl, Stephen J., Garimella, Harisha, Das, Debananda, Wingfield, Paul T., Ghosh, Arun K., Mitsuya, Hiroaki
Publié 2013

Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia

par Ge, Yubin, Dombkowski, Alan A., LaFiura, Katherine M., Tatman, Dana, Yedidi, Ravikiran S., Stout, Mark L., Buck, Steven A., Massey, Gita, Becton, David L., Weinstein, Howard J., Ravindranath, Yaddanapudi, Matherly, Larry H., Taub, Jeffrey W.
Publié 2006

A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity aga...

par Yedidi, Ravikiran S., Garimella, Harisha, Aoki, Manabu, Aoki-Ogata, Hiromi, Desai, Darshan V., Chang, Simon B., Davis, David A., Fyvie, W. Sean, Kaufman, Joshua D., Smith, David W., Das, Debananda, Wingfield, Paul T., Maeda, Kenji, Ghosh, Arun K., Mitsuya, Hiroaki
Publié 2014

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

par Aoki, Manabu, Hayashi, Hironori, Rao, Kalapala Venkateswara, Das, Debananda, Higashi-Kuwata, Nobuyo, Bulut, Haydar, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Yedidi, Ravikiran S, Davis, David A, Hattori, Shin-ichiro, Nishida, Noriko, Hasegawa, Kazuya, Takamune, Nobutoki, Nyalapatla, Prasanth R, Osswald, Heather L, Jono, Hirofumi, Saito, Hideyuki, Yarchoan, Robert, Misumi, Shogo, Ghosh, Arun K, Mitsuya, Hiroaki
Publié dans eLife (2017)