Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia

Children with Down syndrome (DS) with acute megakaryocytic leukemia (AMkL) have very high survival rates compared with non-DS AMkL patients. Somatic mutations identified in the X-linked transcription factor gene, GATA1, in essentially all DS AMkL cases result in the synthesis of a shorter (40 kDa) p...

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Detalhes bibliográficos
Main Authors: Ge, Yubin, Dombkowski, Alan A., LaFiura, Katherine M., Tatman, Dana, Yedidi, Ravikiran S., Stout, Mark L., Buck, Steven A., Massey, Gita, Becton, David L., Weinstein, Howard J., Ravindranath, Yaddanapudi, Matherly, Larry H., Taub, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895418/
https://ncbi.nlm.nih.gov/pubmed/16249385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2219
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