A Unique Role of GATA1s in Down Syndrome Acute Megakaryocytic Leukemia Biology and Therapy

BACKGROUND: Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA1. It is not fully established whether...

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Autori principali: Xavier, Ana C., Edwards, Holly, Dombkowski, Alan A., Balci, Tugce B., Berman, Jason N., Dellaire, Graham, Xie, Chengzhi, Buck, Steven A., Matherly, Larry H., Ge, Yubin, Taub, Jeffrey W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217966/
https://ncbi.nlm.nih.gov/pubmed/22110660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027486
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