RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia

RUNX1 (AML1) encodes the core binding factor α subunit of a heterodimeric transcription factor complex which plays critical roles in normal hematopoiesis. Translocations or down-regulation of RUNX1 have been linked to favorable clinical outcomes in acute leukemias, suggesting that RUNX1 may also pla...

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Detalhes bibliográficos
Main Authors: Edwards, Holly, Xie, Chengzhi, LaFiura, Katherine M., Dombkowski, Alan A., Buck, Steven A., Boerner, Julie L., Taub, Jeffrey W., Matherly, Larry H., Ge, Yubin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756129/
https://ncbi.nlm.nih.gov/pubmed/19638627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-179812
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