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Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
Down syndrome (DS) children have a unique genetic susceptibility to develop leukemia, in particular, acute megakaryocytic leukemia (AMkL) associated with somatic GATA1 mutations. The study of this genetic susceptibility with the use of DS as a model of leukemogenesis has broad applicability to the u...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756130/ https://ncbi.nlm.nih.gov/pubmed/19633202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-190330 |
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