Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

Down syndrome (DS) children have a unique genetic susceptibility to develop leukemia, in particular, acute megakaryocytic leukemia (AMkL) associated with somatic GATA1 mutations. The study of this genetic susceptibility with the use of DS as a model of leukemogenesis has broad applicability to the u...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cabelof, Diane C., Patel, Hiral V., Chen, Qing, van Remmen, Holly, Matherly, Larry H., Ge, Yubin, Taub, Jeffrey W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2009
Pynciau:
Myeloid Neoplasia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756130/
https://ncbi.nlm.nih.gov/pubmed/19633202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-190330
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg