Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications

There is currently no specific therapeutics for the HIV-1-related central nervous system (CNS) complications. Here we report that three newly designed CNS-targeting HIV-1 protease inhibitors (PIs), GRL-083-13, GRL-084-13, and GRL-087-13, which contain a P1-3,5-bis-fluorophenyl or P1-para-monofluorop...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Amano, Masayuki, Salcedo-Gómez, Pedro Miguel, Yedidi, Ravikiran S., Zhao, Rui, Hayashi, Hironori, Hasegawa, Kazuya, Nakamura, Tomofumi, Martyr, Cuthbert D., Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591644/
https://ncbi.nlm.nih.gov/pubmed/31061155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00466-19
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