Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants

We identified GRL-1388 and -1398, potent nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran (Tp-THF). GRL-1388 was as potent as darunavir (DRV) against various drug-resistant HIV-1 laboratory...

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Detalhes bibliográficos
Main Authors: Ide, Kazuhiko, Aoki, Manabu, Amano, Masayuki, Koh, Yasuhiro, Yedidi, Ravikiran S., Das, Debananda, Leschenko, Sofiya, Chapsal, Bruno, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067155/
https://ncbi.nlm.nih.gov/pubmed/21282450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01540-10
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