A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV

In the present study, GRL008, a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI), and darunavir (DRV), both of which contain a P2-bis-tetrahydrofuranyl urethane (bis-THF) moiety, were found to exert potent antiviral activity (50% effective concentrations [EC(50)s...

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Detalhes bibliográficos
Main Authors: Yedidi, Ravikiran S., Garimella, Harisha, Aoki, Manabu, Aoki-Ogata, Hiromi, Desai, Darshan V., Chang, Simon B., Davis, David A., Fyvie, W. Sean, Kaufman, Joshua D., Smith, David W., Das, Debananda, Wingfield, Paul T., Maeda, Kenji, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068604/
https://ncbi.nlm.nih.gov/pubmed/24752271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00107-14
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