P2′ Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety

GRL007 and GRL008, two structurally related nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs) containing 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane (bis-THF) as the P2 moiety and a sulfonamide isostere consisting of benzene carboxylic acid and benzene carboxamide...

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Detalhes bibliográficos
Main Authors: Yedidi, Ravikiran S., Maeda, Kenji, Fyvie, W. Sean, Steffey, Melinda, Davis, David A., Palmer, Ira, Aoki, Manabu, Kaufman, Joshua D., Stahl, Stephen J., Garimella, Harisha, Das, Debananda, Wingfield, Paul T., Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811474/
https://ncbi.nlm.nih.gov/pubmed/23877703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00868-13
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