A comparative study on the efficacies of gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist in neoadjuvant androgen deprivation therapy combined with transperineal p...

nork Miki, Kenta, Sasaki, Hiroshi, Kido, Masahito, Takahashi, Hiroyuki, Aoki, Manabu, Egawa, Shin
Argitaratua izan da BMC Cancer (2016)

Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV...

nork Aoki, Manabu, Das, Debananda, Hayashi, Hironori, Aoki-Ogata, Hiromi, Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Argitaratua izan da mBio (2018)

Non-Cleavage Site Gag Mutations in Amprenavir-Resistant Human Immunodeficiency Virus Type 1 (HIV-1) Predispose HIV-1 to Rapid Acquisition of Amprenavir Resistance but Delay Develop...

nork Aoki, Manabu, Venzon, David J., Koh, Yasuhiro, Aoki-Ogata, Hiromi, Miyakawa, Toshikazu, Yoshimura, Kazuhisa, Maeda, Kenji, Mitsuya, Hiroaki
Argitaratua 2009

Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1

nork Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Ide, Kazuhiko, Das, Debananda, Koh, Yasuhiro, Mitsuya, Hiroaki
Argitaratua 2012

Pulmonary Metastases After Low-Dose-Rate Brachytherapy for Localized Prostate Cancer

nork Kido, Masahito, Kuruma, Hidetoshi, Sasaki, Hiroshi, Miki, Kenta, Aoki, Manabu, Kimura, Takahiro, Takahash, Hiroyuki, Kanehira, Chihiro, Egawa, Shin
Argitaratua 2014

Analysis of prognostic factors in localized high-risk prostate cancer patients treated with HDR brachytherapy, hypofractionated 3D-CRT and neoadjuvant/adjuvant androgen deprivation...

nork Aoki, Manabu, Miki, Kenta, Kido, Masahito, Sasaki, Hiroshi, Nakamura, Wataru, Kijima, Yoshikazu, Kobayashi, Masao, Egawa, Shin, Kanehira, Chihiro
Argitaratua 2014

Do androgen deprivation and the biologically equivalent dose matter in low‐dose‐rate brachytherapy for intermediate‐risk prostate cancer?

nork Tabata, Ryuji, Kimura, Takahiro, Kuruma, Hidetoshi, Sasaki, Hiroshi, Kido, Masahito, Miki, Kenta, Takahashi, Hiroyuki, Aoki, Manabu, Egawa, Shin
Argitaratua izan da Cancer Med (2016)

A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance

nork Aoki, Manabu, Chang, Simon B., Das, Debananda, Martyr, Cuthbert, Delino, Nicole S., Takamatsu, Yuki, Ghosh, Arun K., Mitsuya, Hiroaki
Argitaratua izan da Glob Health Med (2019)

DESIGN, SYNTHESIS, AND EVALUATION OF ANTI-HBV ACTIVITY OF HYBRID MOLECULES OF ENTECAVIR AND ADEFOVIR: EXOMETHYLENE ACYCLOGUANINE NUCLEOSIDES AND THEIR MONOPHOSPHATE DERIVATIVES

nork Imoto, Shuhei, Kohgo, Satoru, Tokuda, Ryoh, Kumamoto, Hiroki, Aoki, Manabu, Amano, Masayuki, Kuwata-Higashi, Nobuyo, Mitsuya, Hiroaki, Haraguchi, Kazuhiro
Argitaratua izan da Nucleosides Nucleotides Nucleic Acids (2015)

Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane That Are Potent against Multi-PI-Resistant HIV-1 Variants In Vi...

nork Tojo, Yasushi, Koh, Yasuhiro, Amano, Masayuki, Aoki, Manabu, Das, Debananda, Kulkarni, Sarang, Anderson, David D., Ghosh, Arun K., Mitsuya, Hiroaki
Argitaratua 2010

Current status and outcomes of patients developing PSA recurrence after prostatectomy who were treated with salvage radiotherapy: a JROSG surveillance study

nork Mizowaki, Takashi, Aoki, Manabu, Nakamura, Katsumasa, Yorozu, Atsunori, Kokubo, Masaki, Karasawa, Katsuyuki, Kozuka, Takuyo, Nakajima, Nobuaki, Sasai, Keisuke, Akimoto, Tetsuo
Argitaratua izan da J Radiat Res (2015)

Human Neutrophil Elastase Induce Interleukin-10 Expression in Peripheral Blood Mononuclear Cells through Protein Kinase C Theta/Delta and Phospholipase Pathways

nork Kawata, Jin, Yamaguchi, Rui, Yamamoto, Takatoshi, Ishimaru, Yasuji, Sakamoto, Arisa, Aoki, Manabu, Kitano, Masafumi, Umehashi, Misako, Hirose, Eiji, Yamaguchi, Yasuo
Argitaratua izan da Cell J (2016)

Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants

nork Ide, Kazuhiko, Aoki, Manabu, Amano, Masayuki, Koh, Yasuhiro, Yedidi, Ravikiran S., Das, Debananda, Leschenko, Sofiya, Chapsal, Bruno, Ghosh, Arun K., Mitsuya, Hiroaki
Argitaratua 2011

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

nork Hayashi, Hironori, Takamune, Nobutoki, Nirasawa, Takashi, Aoki, Manabu, Morishita, Yoshihiko, Das, Debananda, Koh, Yasuhiro, Ghosh, Arun K., Misumi, Shogo, Mitsuya, Hiroaki
Argitaratua 2014

Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation

nork Ghosh, Arun K., Osswald, Heather L., Glauninger, Kristof, Agniswamy, Johnson, Wang, Yuan-Fang, Hayashi, Hironori, Aoki, Manabu, Weber, Irene T., Mitsuya, Hiroaki
Argitaratua izan da J Med Chem (2016)

Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies

nork Ghosh, Arun K., Kovela, Satish, Osswald, Heather L., Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T., Mitsuya, Hiroaki
Argitaratua izan da J Med Chem (2020)

Transperineal prostate brachytherapy, using I-125 seed with or without adjuvant androgen deprivation, in patients with intermediate-risk prostate cancer: study protocol for a phase...

nork Miyakoda Keiko, Takahashi Hiroyuki, Aoki Manabu, Kido Masahito, Sasaki Hiroshi, Kiba Takayoshi, Miki Kenta, Dokiya Takushi, Yamanaka Hidetoshi, Fukushima Masanori, Egawa Shin
Argitaratua 2010-10-01

Transperineal prostate brachytherapy, using I-125 seed with or without adjuvant androgen deprivation, in patients with intermediate-risk prostate cancer: study protocol for a phase...

nork Miki, Kenta, Kiba, Takayoshi, Sasaki, Hiroshi, Kido, Masahito, Aoki, Manabu, Takahashi, Hiroyuki, Miyakoda, Keiko, Dokiya, Takushi, Yamanaka, Hidetoshi, Fukushima, Masanori, Egawa, Shin
Argitaratua 2010

Loss of Protease Dimerization Inhibition Activity of Darunavir Is Associated with the Acquisition of Resistance to Darunavir by HIV-1

nork Koh, Yasuhiro, Aoki, Manabu, Danish, Matthew L., Aoki-Ogata, Hiromi, Amano, Masayuki, Das, Debananda, Shafer, Robert W., Ghosh, Arun K., Mitsuya, Hiroaki
Argitaratua 2011

Adjuvant radiotherapy after prostatectomy for prostate cancer in Japan: a multi-institutional survey study of the JROSG

nork Aoki, Manabu, Mizowaki, Takashi, Akimoto, Tetsuo, Nakamura, Katsumasa, Ejima, Yasuo, Jingu, Keiichi, Tamai, Yoshifumi, Nakajima, Nobuaki, Takemoto, Shinya, Kokubo, Masaki, Katoh, Hiroyuki
Argitaratua 2014