DESIGN, SYNTHESIS, AND EVALUATION OF ANTI-HBV ACTIVITY OF HYBRID MOLECULES OF ENTECAVIR AND ADEFOVIR: EXOMETHYLENE ACYCLOGUANINE NUCLEOSIDES AND THEIR MONOPHOSPHATE DERIVATIVES

Exomethylene acycloguanine nucleosides 4, 6 and its monophosphate derivatives 5, 7, and 8 have been synthesized. Mitsunobu-type coupling of 2-N-acetyl-6-O-diphenylcarbamoylguanine (11) with primary alcohols proceeded regioselectively to furnish the desired N(9)-substituted products in moderate yield...

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Detalhes bibliográficos
Publicado no:Nucleosides Nucleotides Nucleic Acids
Main Authors: Imoto, Shuhei, Kohgo, Satoru, Tokuda, Ryoh, Kumamoto, Hiroki, Aoki, Manabu, Amano, Masayuki, Kuwata-Higashi, Nobuyo, Mitsuya, Hiroaki, Haraguchi, Kazuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7712530/
https://ncbi.nlm.nih.gov/pubmed/26167667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770.2015.1037456
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